PLoS One杂志推出了一个特刊，名称为The Missing Pieces，专门刊发阴性结果，无结果或无法得出结论的研究论文。特刊负面：阴性结果与无结果论文合集

　　PLoS One在业界一直存在争议，有褒有贬，但无论如何，经过短短数年成长，已成为期刊界重要的一分子之一。此次刊发特刊，PLoS的编辑们表示负结果对科学研究同样有价值同样重要，可以向科学家提供平衡的观点，可以节约宝贵的科研投入。

　　The Missing Pieces: A Collection of Negative, Null and Inconclusive Results

　　编辑对此做出了如下评价：

　　The publication of negative, null and inconclusive results is important to provide scientists with balanced information and avoid the duplication of efforts testing similar hypotheses, which waste valuable time and research resources in the process.

　　PLOS ONE considers all work that makes a contribution to the field, independent of impact. This includes negative findings which are valuable to the community in cases where the result is illuminating in the context of previous work.

　　实际上，有关阴性结果论文是否有价值，一直存在争议。在此前还有一本专门刊发阴性结果的期刊问世：Journal of Negative Results in BioMedicine,不过据MedSci编辑查询，目前未进入SCI收录。

　　那么阴性结果，负面结果或无结论结果，是否有价值呢?一般在研究过程中，大家都喜欢阳性结果，尤其是基础研究中，一些阴性结果，往往被冠以“此次实验操作欠佳”而抛弃，最终得出的都是阳性结果。从某种程度上，这种方式已影响到成果的转化。因为大量基础研究成果，到其它实验室并不能很好地重复，甚至不能重复。特刊负面：阴性结果与无结果论文合集

　　不过，临床研究中，一般认为阴性结果可能比较阳性结果更重要。在四大医学期刊中，据有关机构统计，约有30%论文为阴性结果。这一点与基础研究有很大差别。

　　虽然，阴性结果一般被认为是不光彩的，但从科学意义上说，阴性结果同样重要，如果只汇报阳性结果，很容易造成发表偏倚，制造出各种假象。MedSci小编认为，临床研究中，对阴性结果的重视，使得临床研究可重复性很高;而基础研究阴性结果几乎无法发表，这也可能是造成大量基础研究结果难以重复的重要原因之一。

　　研究中如何正确呈现结果，显得至关重要。在最早iPS诱导时，实际上，出现iPS的概率相当低，大量尝试都是失败的，只有极少数能成功诱导出iPS，但最终产生了划时代的成果。而在普通的实验中，如果抛弃阴性结果，可能会带来重要信息的丢失，可能并不利于科学进步。PLoS One对阴性结果的发表，也许推动学界对阴性结果，无法得出结论的结果，给予更客观地评价。

　　当然，MedSci编辑仔细审查这一期合集，并没有读者的担心，虽然都是发表阴性结果或负面结果，但论文质量并不比正刊的质量差。下面列举一些论文：

　　Lack of an Antibacterial Response Defect in Drosophila Toll-9 Mutant.Karine Narbonne-Reveau, Bernard Charroux, Julien Royet.

　　PLOS ONE: published 28 Feb 2011 | info:doi/10.1371/journal.pone.0017470

　　T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses: Implications for Restriction of HIV Replication

　　Randi K. Berg, Stine H. Rahbek, Emil Kofod-Olsen, Christian K. Holm, Jesper Melchjorsen, David G. Jensen, Anne Louise Hansen, Louise B. Jørgensen, Lars Ostergaard, Martin Tolstrup, Carsten S. Larsen, Søren R. Paludan, Martin R. Jakobsen, Trine H. Mogensen

　　PLOS ONE: published 03 Jan 2014 | info:doi/10.1371/journal.pone.0084513

　　Implicitly Priming the Social Brain: Failure to Find Neural Effects

　　Katherine E. Powers, Todd F. Heatherton

　　PLOS ONE: published 20 Feb 2013 | info:doi/10.1371/journal.pone.0056596

　　Impact of a Participatory Intervention with Women’s Groups on Psychological Distress among Mothers in Rural Bangladesh: Secondary Analysis of a Cluster-Randomised Controlled Trial

　　Kelly Clarke, Kishwar Azad, Abdul Kuddus, Sanjit Shaha, Tasmin Nahar, Bedowra Haq Aumon, Mohammed Munir Hossen, James Beard, Anthony Costello, Tanja A. J. Houweling, Audrey Prost, Edward Fottrell

　　PLOS ONE: published 16 Oct 2014 | info:doi/10.1371/journal.pone.0110697

　　A Capsaicin (8%) Patch in the Treatment of Severe Persistent Inguinal Postherniorrhaphy Pain: A Randomized, Double-Blind, Placebo-Controlled Trial

　　Joakim M. Bischoff, Thomas K. Ringsted, Marian Petersen, Claudia Sommer, Nurcan Üçeyler, Mads U. Werner

　　PLOS ONE: published 07 Oct 2014 | info:doi/10.1371/journal.pone.0109144

　　Gameplay as a Source of Intrinsic Motivation in a Randomized Controlled Trial of Auditory Training for Tinnitus

　　Derek J. Hoare, Nicolas Van Labeke, Abby McCormack, Magdalena Sereda, Sandra Smith, Hala Al Taher, Victoria L. Kowalkowski, Mike Sharples, Deborah A. Hall

　　PLOS ONE: published 12 Sep 2014 | info:doi/10.1371/journal.pone.0107430

　　Keratinocytes Propagated in Serum-Free, Feeder-Free Culture Conditions Fail to Form Stratified Epidermis in a Reconstituted Skin Model

　　Rebecca Lamb, Carrie A. Ambler

　　PLOS ONE: published 11 Jan 2013 | info:doi/10.1371/journal.pone.0052494

　　Untrained Chimpanzees (Pan troglodytes schweinfurthii) Fail to Imitate Novel Actions

　　Claudio Tennie, Josep Call, Michael Tomasello

　　PLOS ONE: published 08 Aug 2012 | info:doi/10.1371/journal.pone.0041548

　　High LRRK2 Levels Fail to Induce or Exacerbate Neuronal Alpha-Synucleinopathy in Mouse Brain

　　Martin C. Herzig, Michael Bidinosti, Tatjana Schweizer, Thomas Hafner, Christine Stemmelen, Andreas Weiss, Simone Danner, Nella Vidotto, Daniela Stauffer, Carmen Barske, Franziska Mayer, Peter Schmid, Giorgio Rovelli, P. Herman van der Putten, Derya R. Shimshek

　　PLOS ONE: published 15 May 2012 | info:doi/10.1371/journal.pone.0036581

　　Curated MicroRNAs in Urine and Blood Fail to Validate as Predictive Biomarkers for High-Risk Prostate Cancer

　　Nikhil Sapre, Matthew K. H. Hong, Geoff Macintyre, Heather Lewis, Adam Kowalczyk, Anthony J. Costello, Niall M. Corcoran, Christopher M. Hovens

　　PLOS ONE: published 04 Apr 2014 | info:doi/10.1371/journal.pone.0091729

　　Lack of Evidence for mtDNA as a Biomarker of Innate Immune Activation in HIV Infection

　　Adam S. Lauring, Tzong-Hae Lee, Jeffrey N. Martin, Peter W. Hunt, Steven G. Deeks, Michael Busch

　　PLOS ONE: published 29 Nov 2012 | info:doi/10.1371/journal.pone.0050486

　　Lack of Effect of Lowering LDL Cholesterol on Cancer: Meta-Analysis of Individual Data from 175,000 People in 27 Randomised Trials of Statin Therapy

　　Cholesterol Treatment Trialists' (CTT) Collaboration

　　PLOS ONE: published 19 Jan 2012 | info:doi/10.1371/journal.pone.0029849

　　Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study

　　Mady Hornig, Thomas Briese, Timothy Buie, Margaret L. Bauman, Gregory Lauwers, Ulrike Siemetzki, Kimberly Hummel, Paul A. Rota, William J. Bellini, John J. O'Leary, Orla Sheils, Errol Alden, Larry Pickering, W. Ian Lipkin

　　PLOS ONE: published 04 Sep 2008 | info:doi/10.1371/journal.pone.0003140

　　The Influence of Partner-Specific Memory Associations on Picture Naming: A Failure to Replicate Horton (2007)

　　Sarah Brown-Schmidt, William S. Horton

　　PLOS ONE: published 03 Oct 2014 | info:doi/10.1371/journal.pone.0109035

　　Why Publishing Everything Is More Effective than Selective Publishing of Statistically Significant Results

　　Marcel A. L. M. van Assen, Robbie C. M. van Aert, Michèle B. Nuijten, Jelte M. Wicherts

　　PLOS ONE: published 17 Jan 2014 | info:doi/10.1371/journal.pone.0084896

　　Failing the Future: Three Unsuccessful Attempts to Replicate Bem's ‘Retroactive Facilitation of Recall’ Effect

　　Stuart J. Ritchie, Richard Wiseman, Christopher C. French

　　PLOS ONE: published 14 Mar 2012 | info:doi/10.1371/journal.pone.0033423

　　Priming of Social Distance? Failure to Replicate Effects on Social and Food Judgments

　　Harold Pashler, Noriko Coburn, Christine R. Harris

　　PLOS ONE: published 29 Aug 2012 | info:doi/10.1371/journal.pone.0042510

　　Two Failures to Replicate High-Performance-Goal Priming Effects

　　Christine R. Harris, Noriko Coburn, Doug Rohrer, Harold Pashler

　　PLOS ONE: published 16 Aug 2013 | info:doi/10.1371/journal.pone.0072467

　　Failure to Replicate Depletion of Self-Control

　　Xiaomeng Xu, Kathryn E. Demos, Tricia M. Leahey, Chantelle N. Hart, Jennifer Trautvetter, Pamela Coward, Kathryn R. Middleton, Rena R. Wing

　　PLOS ONE: published 21 Oct 2014 | info:doi/10.1371/journal.pone.0109950

以上为德瑞所收集的重要资料，希望可以第一时间帮到您，专业并提供SCI论文修改，润色，翻译，课题设计，基金申请，数据统计，实验委托等服务。专业阅读：医学论文之医学教学革新举措与成效分析