撰写Cover Letter的主要目的是告知编辑研究的要点，其主要方式如下：
1. 总结陈述所研究领域的研究状况，直接指出研究中的Gap(未解决的问题)。
2. 指出本文欲解决的问题。
3. 投稿声明，未有“一稿多投”，所有作者都查看了Manuscript，并同意投稿。
样例：
DearEditor,
We would like to submit our manuscript with the title of “论文题目” to the Journal of XXas an original article. 我们欲投稿(论文题目)到贵刊，作为论著刊发。
Telomerase activity has been considered as an important marker for the pathogenesis of cancer. To date, there are still disputes on the telomerase activity in the somaticcells as and cancer cells. [列举当前研究进展，指出当前的争议问题] In this study, a new method was designed to determine the activity of telomerase in somatic cells and NSCLC cancer cells. Our study indicated that no expression of telomerase was identified in somatic cells, while elevated telomerase activity was noticed in the cancer cells [本研究结果表明体细胞内未检测到端粒酶活性，而肿瘤细胞检测到该活性]. Targeted therapy has beenconsidered as an effective treatment plan for NSCLC. In this study, theTERT-based targeted therapy was designed to eliminate the potential toxicity to the somatic cells [设计基于TERT的靶向治疗方案]. Our study revealed a significantly increased survival rate in rats with ectopic tumor treated by TERT-basedtargeted therapy than the conventional chemotherapy [所得结果].
注意：本文仅为示例，阐述的内容为随意杜撰，不具科学依据。
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